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In April 2021, WHO published an article entitled "Deafness and hearing loss", in which it stated that more than 5% of the world's population, or around 430 million people lost the ability to hear, and about 34 million of them were children. Sign language is a way or means for deaf and speech-impaired individuals to communicate and stay connected with the rest of the world and express ideas, from which there is a great need for efficient and cost-effective translation software or tools in the modern world to accurately understand what individuals with disabilities want to express,  in this research project produced a software system to translate sign language into a natural language such as Indonesian for real-time communication, The translated data will imply the alphabet related to movements captured directly through the camera by utilizing  SSD-MobileNet algorithm that has a light computing load but with high accuracy results up to more than 98%.